Family Guy is a comedy on FOX that is a fan favorite. It it so popular that it has been canceled twice, only to be brought back at the public's demand. It is hilarious, kind of a version 2.0 of The Simpsons.
The show is about the Griffins. Peter is the father, fat and slow witted, kind of a Homer Simpson rip-off. He's married to Lois, the smart woman that tries to keep the family sane (Marge Simpson?). Their kids are Chris, the dumb younger version of Peter; Meg, the unpopular reject, and Stewie, the sometimes evil sophisticated baby that can talk, in an English accent. His quotes are the best. Also, Brian is the dog that can talk and is accepted as part of society. Stewie and Peter compete for my favorite character. Minor characters are also funny, like Tom Tucker, Quagmire, and Mayor Adam West.
Funny moments come when flashbacks are shown, usually when a character mentions them, referencing other things. Like this. Also, when it goes to the extreme. Or, when it doesn't even make sense.
The show is now on FOX, TBS, DVD, and in syndication. Here's their website if you can't get enough.